Instrumentation

The Tracera TS-1 is a general-purpose, computer-controlled radiochemistry synthesis module for producing a wide variety of compounds.

Click HERE for additional information on the Tracera TS-1 (PDF File)

Several synthesis procedures have been or are being developed for the
TS-1, including:

1. 1-[¹⁸F]Fluoro-3-(2-nitro-imidazol-1-yl)-propan-2-ol
([¹⁸F]Fluoromisonidazole, (FMISO)

2. p-[¹⁸F]fluorobenzylguanidine (PFBG)

3. Fluorodeoxyglucose (FDG)

4. 3-[¹⁸F]fluoro-3-deoxy-L-thymidine (FLT)

5. 16-a-[¹⁸F]fluoroestradiol-17b (FES)

6. 9-(4-[¹⁸F]fluoro-3-hydroxymethylbutyl)guanine (FHBG),
F-18 labeled gene reporter probe

7. ¹⁸F-Galacto-RGD

TS-1 Features

• Compact size fits into standard mini-hot cell

• Two reactors allow two-pot syntheses, and with intermediate clean cycles, multi-pot syntheses

• Prep-HPLC and SPE purifications

• Maximal flexibility for complex, multi-step processes

• Formulation by trap-and-release or evaporation

• Self cleaning cycle allows back-to-back runs without operator intervention

• Multiple radioisotopes and chemistries

• Simple USB connection to control computer

• Teflon tubing and valves are compatible with harsh organic solvents,
acids and bases

• “On-the-fly” specific activity measurement for UV-active compounds or intermediates

• Input activity estimation for [¹⁸F]fluoride or gaseous precursors

• cGMP compliant software

TS-1 Advantages

Flexible and Reliable Chemistries
The TS1 module has the capability of synthesizing radiopharmaceuticals using a variety of isotopes and chemistries, including cyclotron and generator-produced radioisotopes (e.g. ¹¹C, ¹⁸F, and ⁶⁴Cu. The module isolates labeling intermediates and products using solid phase extraction (SPE) or semi-preparative HPLC purification. Its functionality includes a leak test and a clean-cycle that cleanses the unit to ensure reliability of product with minimal long-term maintenance. An extensive R&D program ensured maximal flexibility of the system to produce a wide array of products. Reliability has been built into the software through constant status feedback of the control systems.

Advanced Electronic Control & User Interface
The TS-1 module is controlled by a notebook computer via a single USB interface cable. The HPLC pump and UV detector electronics are housed outside the hot-cell. A dedicated software interface allows both automatic and manual control of all operations. Parameters for automated synthesis are easily changed within an Excel file. Comprehensive reports are generated as Excel files for documentation and analysis purposes. New synthetic procedures are developed quickly through a real-time parameter-recording feature. When the program is in automatic mode, the manual controls shown on the screen activate in sequence so the operator can track the progress of the synthesis routine. User intervention can be disabled for controlled cGMP production. A strip-chart plot of the radioactivity monitors and HPLC UV detector is provided for quality assurance purposes and for troubleshooting. A user’s manual and video tutorial aid in the setup, operation and quality control procedures associated with production of radiotracers.

This unit is currently available. Contact Tracera for further information.